Anti-malaria and hypoglycaemic activities of Diosgenin on alloxan-induced, diabetic Wistar rats

The rising threat of Plasmodium falciparum resistance to Monotherapies has prompted the world health organization (WHO) 2006 guidelines recommend use different anti-malarias. In this study, anti-malaria and hypoglycaemic activities Diosgenin, a potent, yet poorly reported saponin was investigated on P. inoculated Alloxan-Induced, Diabetic Wistar Rats. Fort two (42) adult male wistar rats between 100g 150g were procured, acclimatized (for weeks), grouped into seven six (6) per group. While Group 1 (Normal control) received normal rat chow water ad libitum, groups 2 – 4 no treatment (untreated), 10 mg/kg body weight anti-diabetic Metformin 25 diosgenin respectively after inducing diabetes mellitus (DM) with alloxan monohydrate; whereas, 5-7 (all malaria infected) untreated (negative control), 56 coartem respectively. Following period, blood samples obtained assayed for fasting sugar, packed cell volume (PCV) total white count (TWBCC). From result, exposed showed lowered PCV values than control observed improvements in (significant at p < 0.05) (insignificant) groups. Also, diabetic, treated an insignificant reduction sugar levels compared control, even though change apparently improved Again, TWBCC caused notable decrease treated, signified huge recovery rats. Corroborative studies other systems is recommended.